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吴志民

一、基本信息

 姓名:吴志民    

 职称:教授

 籍贯:湖南汨罗

 邮箱:xdwuzm@xtu.edu.cn

 办公室:化学化工大楼C-603

 主页:/info/1020/4333.htm

    吴志民 教授/博士生导师化工系主任,在精细有机化工和医药化工领域从事微结构化学品的结构-性能关系研究,应用于催化反应、高分子合成与纳米药物传输系统。在《ACS Applied Materials and Interfaces》、《Composites Part B: Engineering》、International Journal of Pharmaceutics》、《Pharmaceutics》、《Colloids and Surfaces B: Biointerfaces》、《Materials letters》、ChemCatChem》、《Catalysis Science and Technology》、《RSC Advances》、《 Progress in Organic Coatings》、《高校化学工程学报》、《化学学报》、《分子催化》等刊物第一作者(通讯作者)发表SCI论文近20余篇;授权美国发明专利2项、授权中国发明专利5项。现主持国家科技部重点研发项目1项(2020YFB0311701)、湖南省自然科学基金面上项目1项(2020JJ4091)湖南省教育厅优秀青年基金项目1项(18B068)及横向项目2已主持完成国自科基金青年科学基金项目(21406187)、中国博士后基金项目(2014M552143)、湖南省自然科学基金项目(14JJ3080)、湖南省教育厅一般项(13C912)等项目

本科教学与实践

    湖南省教学成果奖一等奖(排名第3),主讲《化工热力学(陈钟秀,第三版,第567章)》、《文献检索》、《药用高分子材料》、《制药工程工艺设计》、《药品生产质量管理工程》;《毕业设计》专注特种蒸发设备设计与实践,《毕业论文》专注精细化学品及聚合物单体催化合成工艺、高分子纳米药物载体材料的设计与合成;指导大学生创新实验和全国化工、制药工程设计大赛。

研究生招

    本课题组每年招收研究生3-5名,包含化工、新材料和制药三大方向,欢迎化学工程与工艺、高分子材料、制药工程及应用化学专业学生报考。接受调剂,欢迎有意者发邮件联系!

学习工作经历

2021.12-至 今

2016.1-2021.12

2013.2-2017.05

2012.7-2015.12

 湘潭大学 化工学院 化工与制药工程系,教授/硕导

 湘潭大学 化工学院 化工与制药工程系,副教授/硕导

 湘潭大学 工学院 化工与制药工程系,博士后

 湘潭大学 化工学院 化工与制药工程系,讲师/硕导

 研究方向:精细有机化工与医药化工

2007.9-2012.3

 华南理工大学 化学与化工学院化学工程专业 博士 导师钱宇章莉娟教授

 专业方向:化学产品工程

2004.9-2007.6

 昆明理工大学 化工学院化学工程专业 硕士 导师顾丽莉教授

 专业方向:化工传质与分离

1999.9-2004.6

 广东石油化工学院 化工学院化学工程与工艺专业 学士

 广东石油化工高等专科学校 化工学院 高分子材料与工程专业

 专业方向:精细有机化工


二、主要代表性成果    

(一)期刊论文

Fuqiang Li, Zhong Liang, Yuxing Li, Zhimin Wu*, Zhengming Yi*. Synthesis of waterborne polyurethane by inserting polydimethylsiloxane and constructing dual crosslinking for obtaining the superior performance of waterborne coatings, Composites Part B: Engineering, 2022, 238, 109889.

Zhong Liang, Jiantao Zhu, Fuqiang Li, Zhimin Wu*, Yuejin Liu*, Di Xiong. Synthesis and properties of self-crosslinking waterborne polyurethane with side chain for water-based varnish, Progress in Organic Coatings, 2021, 150, 105972.

Wenqi Teng, Zhaogang Yang, Suiping Wang, Di Xiong*, Yifei Chen, Zhimin Wu*. Toxicity evaluation of mesoporous silica particles Santa Barbara No. 15 amorphous in human umbilical vein endothelial cells: influence of particle morphology, Journal of Applied Toxicology, 2021, 41(6).

Chao Yu, Xing Tan, Zhenzhu Xu, Guodian Zhu, Wenqi Teng, Qingzhen Zhao, Zhong Liang, Zhimin Wu*, Di Xiong*. Smart drug carrier based on polyurethane material for enhanced and controlled DOX release triggered by redox stimulus, Reactive and Functional Polymers, 2020, 148, 104507.

Chao Yu, Lei Wang, Zhenzhu Xu, Wenqi Teng, Zhimin Wu*, Di Xiong*, Smart micelle self-assembled from four-arm star polymers as potential drug carriers for pH-triggered DOX release, Journal of Polymer Research, 2020, 27, 111.

Zhi Min Wu*, Manzhen Duan, Di Xiong, Can Yang Zhang*. Mesoscale Simulations of pH-Responsive Amphiphilic Polymeric Micelles for Oral Drug Delivery. Pharmaceutics, 11(12): 620, 2019.

Wen Yao Hu, Zhi Min Wu*, Qian Qian Yang, Yue Jin Liu, Juan Li, Can Yang Zhang*. Smart pH-responsive polymeric micelles for programmed oral delivery of insulin. Colloids and Surfaces B: Biointerfaces, 183: 110443, 2019.

Jiantao Zhu, Zhi Min Wu*, Di Xiong, Langsheng Pan, Yuejin Liu*. Preparation and properties of a novel low crystallinity cross-linked network waterborne polyurethane for water-based ink. Progress in Organic Coatings, 133: 161-168, 2019.

Ning Liu, Zhi Min Wu*, Meng Li, Shanshan Li, Yong-Fei Li, Rongdong Yu, Lang-Sheng Pan, Yue Jin Liu*. A novel strategy for constructing mesoporous solid superbase catalysts: bimetallic Al-La oxides supported on SBA-15 modified with KF. Catalysis Science and Technology, 7, 725-733, 2017.

Yan Wang, Bo Zhi Chen, Yue Jin Liu, Zhi Min Wu*, Xin Dong Guo*. Application of Mesoscale simulation to explore the aggregate morphology of pH-sensitive nanoparticles used as the oral drug delivery carriers under different conditions. Colloids and Surfaces B: Biointerfaces, 151, 280-286, 2017.

Ning Liu,  Zhimin Wu* ,  Meng Li ,  Shanshan Li ,  Zhantao Luo , Yongfei Li ,  Langsheng Pan ,  Yuejin Liu*. Low-temperature preparation of mesoporous silica superbase by using multifunction of a La2O3 interlayer. ChemCatChem,  9(9): 1641-164, 2016.

Yan Wang, Jia Wei Ren, Can Yang Zhang, Meng Chan He, Zhi Min Wu* and Xin Dong Guo*, Compatibility studies between amphiphilic pH-sensitive polymer and hydrophobic drug using multiscale simulations, RSC Advances, 6, 101323-101333, 2016.

Danfeng Wang, Zhicheng He, Zhi Min Wu*, Ying Tan, Yongfei Li, Yuejin Liu*, Highly selective synthesis for 4,4′-bisphenol F from phenol and formaldehyde catalyzed with [C4mim][HSO4] ionic liquid, Chinese Journal of Chemical Engineering, 24(9), 1166-1170, 2016.

Meng Li, Ning Liu, Zhimin Wu*, Yongfei Li, Shanshan Li, Wenzhi Xu, Zhantao Luo, Yuejin Liu*, A facile and novel route for dual-template method synthesis of mesoporous silica material Al-Ce-SBA-15, Materials Letters, 185(15), 85-88, 2016.

Yan Wang, Qiu Yu Li, Xu Bo Liu, Can Yang Zhang, Zhi Min Wu*, Xin Dong Guo*. Mesoscale Simulations and Experimental Studies of pH-Sensitive Micelles for Controlled Drug Delivery, ACS Applied Materials and Interfaces, 7 (46), 25592-25600, 2015.

Yan Wang, Dan Dan Zhu, Jian Zhou, Qi Lei Wang, Can Yang Zhang, Yue Jin Liu, Zhi Min Wu*, Xin Dong Guo*. Mesoscopic simulation studies on the formation mechanism of drug loaded polymeric micelles, Colloids and Surfaces B: Biointerfaces, 136, 536-544, 2015.

Qing Wang, Zhi Min Wu*, Yongfei Li, Ying Tan, Ning Liu and Yuejin Liu*, The efficient hydroxyalkylation of phenol with formaldehyde to bisphenol F over a thermoregulated phase-separable reaction system containing water-soluble Bronsted acidic ionic liquid, RSC Advances, 63(4), 33466-33473, 2014.

何志成, 吴志*, 李勇飞, 王庆, 潘浪胜, 刘跃进*. 磺酸功能化双核离子液体催化合成双酚F, 分子催化, 28(6), 533-542, 2014.

王庆, 刘杰, 吴志民, 李勇飞, 肖丹, 田娟, 谈瑛, 刘跃进*. Br?nsted酸性离子液体催化苯酚羟烷基化反应合成双酚F, 高校化学工程学报, 28(4), 758-763, 2014.

Zhi Min Wu, Liying Zhou, Xin Dong Guo, Wei Jiang, Li Ling, Yu Qian, Kathy Qian Luo, Lijuan Zhang*. HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin, International Journal of Pharmaceutics, 425(1-2), 1-8, 2012.

Zhi Min Wu, Xin Dong Guo, Li Juan Zhang*, Wei Jiang, Li Ling, Yu Qian, and Yun Chen. Solvent mediated microstructure and release behavior of insulin from pH-sensitive nanoparticles, Colloids and Surfaces B: Biointerfaces, 94, 206-212, 2012.

Zhi Min Wu, Li Ling, Li Ying Zhou, Xin Dong Guo, Wei Jiang, Yu Qian, Kathy Qian Luo, and Li Juan Zhang*. Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery, Nanoscale Research Letters, 7, 229-236, 2012.

WU Zhimin, JIANG Wei, YANG Youqiang, ZHOU Liying, LING Li, XU Feng, GUO Xindong, ZHANG Lijuan. mPEGylation of Insulin and Characterization of Its Activity. Acta Chim. Sinica, 69(23): 2889-2895, 2011.

Xin Dong Guo, Li Juan Zhang, Zhi Min Wu, Yu Qian*, Dissipative particle dynamics studies on microstructure of pH-sensitive micelles for sustained drug delivery, Macromolecules, 43(18), 7839-7844, 2010.

章莉娟*, 陈悦毫, 杨友强, 蓝荣肇, 吴志民, 李庆阳, 郭新东. ATRP法合成两亲性聚乙二醇-聚丙烯酸叔丁酯嵌段共聚物, 高校化学工程学报, 25(5), 781-786, 2011.

Xin Dong Guo, Li Juan Zhang, Zhi Min Wu, Yu Qian*, Studies on pH-sensitive micellar structures for sustained drug delivery: Experiments and computer simulations. Journal of Controlled Release, 152 (1 Supplement 1), e26-e28, 2011


(二)专利


吴志民, 谢坚韧, 刘跃进,甘杰, 胡文尧. 光诱导微量铜催化合成纳米载体材料pH响应共聚物的方法, 2018.10, 中国, CN 105461850 B.

吴志民, 曲艺, 沈毓媛, 刘跃进, 潘浪胜, 李勇飞. 一种邻苯二胺缩苯甲醛双席夫碱钯配合物催化合成氟苯水杨酸的方法, 2018.6, 中国,CN 105254485B.

吴志民, 胡文尧, 刘跃进, 谢坚韧. 一种pH响应/膜粘附两亲性嵌段共聚物及其制备方法, 2016.8, 中国, 201610659104.2

Lijuan Zhang, Li Ling, Li Ying Zhou, Zhi Min Wu, Xin Dong Guo, Wei Jiang, Qian Luo, Yu Qian. pH-sensitive nanoparticles for oral insulin delivery, 2014.10.14, US 8859004B2.

Lijuan Zhang, Yu Qian, Zhi Min Wu, Li Ying Zhou, Wei Jiang, Qian Luo, Ling Li, Xin Dong Guo. Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery, 2015.8.11, US9101547B2.

章莉娟,凌莉,周丽英,吴志民,郭新东,蒋薇,罗茜,钱宇. 用于口服胰岛素递送的pH敏感性纳米粒子,2014.08.13中国,CN102908627B.

钱宇,章莉娟,吴志民,周丽英,蒋薇,凌莉,罗茜,郭新东. 用于口服胰岛素递送的包含阳离子纳米粒子的肠溶包衣胶囊,2014.04.16,中国,CN102908332B.

章莉娟, 蒋薇, 吴志民, 钱宇, 凌莉, 郭新东. 一种口服聚乙二醇化胰岛素pH敏感纳米粒及其制备方法,2013.02.13,中国,CN102293748B


(三)会议论文


Zhi Min Wu*, Wen Yao Hu and Teng Fei Lu, The pH-responsive/mucoadhesive Polymeric Micelles for Oral Delivery of Insulin, Abstracts of the BIT’S 6rd Annual Symposium of Drug Delivery System 2016, Sym 201, Nanjing, China, Speaker in Symposium 2: Smart Materials and Devices for Drug Delivery.

谢坚韧, 胡文尧, 甘杰, 吴志民*, 光化学ATRP法合成共聚物P(MMA-co-tBMA), 全国高分子学术论文报告会, 2015.

Zhi Min Wu*, Nanoparticles strategies for oral insulin: Fact of Fiction? Abstracts of the BIT’S 3rd Annual Symposium of Drug Delivery System 2013, 235, Haikou, China, Speaker in Session 3-1: New Oral, Transmucoadhesivie and Buccal Drug Delivery.